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What is α-Acetylbutyrolactone  CAS 517-23-7（raw material）

α-Acetylbutyrolactone cas 517-23-7, the chemical name a-Acetyl-g-hydroxybutyric Acid g-Lactone, is a transparent to slightly yellow liquid, its Ester-like odour liquid. and its molecular formula is C6H8O3. It’s used in the manufacture of drugs such as vitamin B1 and delays the pain.It’s also an important intermediate in the synthesis of vitamin B. It is also an intermediate for the synthesis of 3,4-disubstituted pyridine and 5-(β-hydroxyethyl)-4-methyl thiazole. Acetobutyrolactone is an intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.

α-Acetylbutyrolactone  CAS 517-23-7 Interactions

α-Acetylbutyrolactone is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methyl thiazole.

In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl(E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.

2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine which is a leading therapeutic agent for the treatment of narrow and wide-angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officer or other reported methods.

a-Acetobutyrolactone is an intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.

Pharmacological action of α-Acetylbutyrolactone  CAS 517-23-7

1. Acetobutyrolactone is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methyl thiazole.

What is α-Acetylbutyrolactone CAS 517-23-7 Used for

For Research&Development use only. For industry use only.Not for medicinal, household or other use.

How to keep in store for α-Acetylbutyrolactone CAS 517-23-7

Sealed and protected from light.

Packaged in aluminium drums, the specification is 100kg. Storage and transportation according to the regulations of flammable and toxic chemicals.

The stability of  α-Acetylbutyrolactone CAS 517-23-7

Use and store according to specifications, without decomposition, and avoid contact with oxides

This product has certain toxicity and can stimulate the skin and mucous membranes. The workshop should be ventilated, the equipment should be airtight, and the operator should wear protective equipment.

Exist in the flue gas.

It turns blue to blue-red-purple when exposed to iron.

First-aid measures of α-Acetylbutyrolactone CAS 517-23-7

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move the person into the fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Accidental release measures of α-Acetylbutyrolactone CAS 517-23-7

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let the product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Precautions for safe handling of α-Acetylbutyrolactone CAS 517-23-7

Avoid contact with skin and eyes. Avoid the formation of dust and aerosols. Avoid exposure – obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed.

Conditions for safe storage, including any incompatibilities

Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place.

Appropriate engineering controls of α-Acetylbutyrolactone CAS 517-23-7

Handle in accordance with good industrial hygiene and safety practices. Wash hands before breaks and at the end of the workday.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching the glove’s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear a dust mask when handling large quantities.

Where to buy α-Acetylbutyrolactone CAS 517-23-7

α-Acetylbutyrolactone CAS 517-23-7 used in the manufacture of drugs such as vitamin B1 and delaying pain, it is is a transparent to slightly yellow liquid, its Ester-like odour liquid.

 α-Acetylbutyrolactone CAS 517-23-7 is available online from different manufacturers.

Most users of α-Acetylbutyrolactone CAS 517-23-7 buy from different websites, some for retail or wholesale purposes.

Verify the legitimacy of every α-Acetylbutyrolactone CAS 517-23-7 manufacturer using outlined state laws before purchase.

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Reference

1.Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.

2.Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of

3. 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.

4.Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.

5.Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.