Pregabalin: All you should know about it
What is Pregabalin?
The Us NCI dictionary declares the definition of pregabalin as A drug used to treat nerve pain caused by diabetes or herpes zoster infection and certain types of seizures. It is being studied in the prevention and treatment of nerve pain in the hands and feet of cancer patients given chemotherapy. Pregabalin is a type of anticonvulsant. Also called Lyrica.
Pregabalin is a type of anticonvulsant. Also called Lyrica.
As on NHS, this is how Pregabalin is described:
Pregabalin is used to treat epilepsy and anxiety.
It’s also taken to treat nerve pain. Nerve pain can be caused by different conditions including diabetes and shingles, or an injury.
-Pregabalin works in different ways:
In epilepsy, it stops seizures by reducing the abnormal electrical activity in the brain
with nerve pain, it blocks pain by affecting the pain messages travelling through the brain and down the spine
In anxiety, it stops your brain from releasing the chemicals that make you feel anxious
How should Pregabalin be used?
Pregabalin comes as a capsule, an oral solution, and as an extended-release tablet to take by mouth. Pregabalin capsules and oral solution are usually taken with or without food two or three times a day. Pregabalin extended-release tablets are usually taken once daily after an evening meal. Take pregabalin at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Swallow the extended-release tablets whole; do not cut, chew, or crush them.
Your doctor will probably start you on a low dose of pregabalin and may gradually increase your dose during the first week of treatment.
Take pregabalin exactly as directed. Pregabalin may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.
Pregabalin may help control your symptoms but will not cure your condition. It may take several weeks or longer before you feel the full benefit of pregabalin. Continue to take pregabalin even if you feel well. Do not stop taking pregabalin without talking to your doctor, even if you experience side effects such as unusual changes in behaviour or mood. If you suddenly stop taking pregabalin, you may experience withdrawal symptoms, including trouble falling asleep or staying asleep, nausea, diarrhoea, headaches, or seizures. Your doctor will probably decrease your dose gradually over at least 1 week.
Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with pregabalin and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the manufacturer’s website to obtain the Medication Guide.
What special precautions should I follow before I take Pregabalin?
- Tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Also tell your doctor if you have or have ever had swelling of the eyes, face, lips, tongue, or throat; vision problems; heart failure; bleeding problems or a low number of platelets (type of blood cell needed for blood clotting) in your blood, or lung, heart, or kidney disease. Do not drink alcohol while taking pregabalin. Alcohol can add to the drowsiness caused by this medication.
- Tell your doctor and pharmacist if you are allergic to pregabalin, any other medications, or any of the ingredients in pregabalin preparations. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten, in Capozide), enalapril (Vasotec, in Vaseretic, Lexxel), fosinopril (Monopril), lisinopril (Prinivil, Zestril, in Prinzide, Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); antidepressants; antihistamines; medications for anxiety including lorazepam (Ativan); medications for mental illness or seizures; certain medications for diabetes such as pioglitazone (Actos, in Duetact) and rosiglitazone (Avandia, in Avandaryl, Avandamet); opioid (narcotic) pain medications including hydrocodone (in Hydrocet, in Vicodin, others), morphine (Avinza, Kadian, MSIR, others), or oxycodone (OxyContin, in Percocet, others); sedatives; sleeping pills; and tranquillizers.
- Tell your doctor if you are pregnant or if you or your partner plans to become pregnant. Also tell your doctor if you are breastfeeding. If you or your partner becomes pregnant while you are taking pregabalin, call your doctor. Pregabalin has caused decreased fertility in male animals and birth defects in the offspring of male and female animals who were treated with the medication. There is not enough information to tell if pregabalin causes these problems in humans.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pregabalin.
- You should know that pregabalin may make you dizzy or drowsy. Do not drive a car operate machinery, or do other dangerous activities until you know how this medication affects you. Ask your doctor when you may do these activities.
- There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as pregabalin, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behaviour; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying; or any other unusual changes in behaviour or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
What side effects can Pregabalin cause?
Tell your doctor if any of these symptoms are severe or do not go away:
- speech problems
- dry mouth
- lack of coordination
- weight gain
- ”high” or elevated mood
- difficulty concentrating or paying attention
- difficulty remembering or forgetfulness
- back pain
- loss of balance or unsteadiness
- uncontrollable shaking or jerking of a part of the body
- muscle twitching
- increased appetite
If you have diabetes, you should know that pregabalin has caused skin sores in animals. Pay extra attention to your skin while taking pregabalin, and tell your doctor if you have any sores, redness, or skin problems.
Where can I find Pregabalin raw material for my business purpose?
If you are looking for pregabalin raw material, you can take a look at our shop page.
Here is the COA by our internal test:
Pregabalin Certificate of Analysis
Name of Product
White or almost white powder
IR Spectrum of sample should match that of Pregabalin
The retention time of main peak of test sample should match that of reference solution in the test of enantiomeric purity.
Sparingly soluble in water, very slightly soluble in methanol.
Any unspecified impurity
98.0% - 102.0%