Sesamol Mechanism Of Action and Main Function

1. What is sesamol?

Sesamol, together with its conjugated metabolites, is distributed in body tissues like the liver, brain, lungs as well as kidneys. When Sesamol is absorbed in the body, it protects DNA from damage and enhances DNA repair to rectify after-radiation damage. Because of its varied Vivo bioactivities, sesamol plays an essential role in treating various diseases. One study established that sesamol inhibits the HepG2 cell colony formation. This supports other studies that suggest that Sesamol powder (533-31-3) ruins the viability of the cancer cells. Normally, the majority of cancer cells need more oxidative stress as compared to healthy cells in order to maintain the proliferation-apoptosis balance. Some studies indicate that the interaction of sesamol and DNA is likely to take place at the latter s groove. Still on that, another research study shows that the cell cycle induced by sesamol arrest at the S phase happens in a concentration-dependent way. This is how sesamol causes DNA damage and obstructs the replication of DNA.


2. Sesamol General Description

Sesamol is a natural organic compound which is a component of sesame oil. Sesamol has been found to be an antioxidant that may prevent the spoilage of oils and may protect the body from damage from free radicals. It also may prevent the spoilage of oils by acting as an antifungal. Sesame oil is used in Ayurvedic medicine and sesamol may play a key role in this traditional field. Sesamol possesses a number of pharmacological properties which include anti-inflammatory, antioxidant, and neuroprotective properties. Sesamol pretreatment offers radioprotection and prevents radiation-induced chromosomal aberrations in human blood lymphocytes. Sesamol powder is a crop that is grown for the oil in its seed. It is found in tropical and subtropical areas of Asia, Africa, and South America. Compared to similar crops, such as peanuts, soybean, and rapeseed, the seeds of sesame are believed to have the most oil. Sesame seeds are also rich sources of protein, vitamins, and antioxidants. People take sesame by mouth for Alzheimer s disease, anaemia, arthritis, heart disease prevention, cataracts, constipation, high cholesterol, infertility in men, menopause, osteoporosis, pain, stomach ulcers, stomach cancer, stroke, and weight loss. People apply sesame oil to the skin for ageing skin, hair loss, anxiety, frostbite, psoriasis, warts, wound healing, pain, and to prevent bug bites. People use sesame oil injections to improve their vocal cords. In foods, sesame oil is used as cooking oil and to make dressings and sauces. Sesame seeds are added to food for flavouring.

3. Sesamol Mechanism Of Action and Main Function

Sesamol contains chemicals that help to reduce swelling and increase how quickly skin wounds heal. These chemicals might slow how fast sugar is absorbed from food. This might help people with diabetes. Sesame might also eliminate bacteria that cause plaque. Sesame contains calcium, which might help treat rickets.

Sesamol Main Function:

  1. Sesamol has an effect on improving the lipid profile;
  2. Sesamol has the function of normalizing blood pressure;
  3. Sesamol can be used for losing weight;
  4. Sesamol can increase ketone production;
  5. Sesamol also has the function of anti-inflammatory. Sesamin has an effect on antiviral, fungicides, antioxidants, and insecticide synergists.
  6. Sesamol can also be used in the treatment of bronchitis.
  7. Sesamol has the function of inhibiting the influenza virus, Sendai virus and Mycobacterium tuberculosis.

4. Sesamol benefits for neuroprotection

The major benefit of sesamol is Neuroprotection and here s how it offers that:

  • Brain insulin signalling pathway regulation

Sesamol plays a significant role in the regulation of the insulin signalling pathway in the brain. The antioxidant activated the IRS-1/AKT molecular pathway, and this makes the body respond more quickly to insulin level changes. In addition to making your body more sensitive to insulin fluctuations, sesamol promotes the metabolism of brain energy as well as the brain cells. It minimizes the levels of blood glucose levels and boosts Streptozotocin (STZ), which is primarily meant to deter the functionality of the beta cells that are responsible for the production of insulin in the pancreas.

  • Neurodegenerative disease regulation

The oxidating compound achieves that by boosting the brain s oxidative stress. This reduces the production and release of the substances that might result in cancer-causing inflammations. Besides, the functionality of the barrier between the blood and the brain is improved. As a result, a person’s susceptibility to brain conditions such as Alzheimer s disease and neurodegenerative lesions is minimized. This also means that a person who already has brain structural abnormalities as a result of old age or Alzheimer’s disease, among other brain-related issues, can experience relief of the related symptoms should they use sesamol as recommended. Research shows that sesamol increases acetylcholine transferase (ChAT) activity as well as Acetylcholine (Ach) levels. Ach is among vital central cholinergic system neurotransmitters.

At the same time, the oxidant reduces the activity of cholinesterase (AchE). As such, researchers have established that sesamol has a positive effect on learning as well as memory function in humans.

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