CAS 224785-91-5 Product Description
| Product Name: | CAS 224785-91-5 |
| Synonyms: | 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride |
| CAS NO: | 224785-91-5 |
| EINECS: | 606-590-1 |
| Molecular Formula: | C23H33ClN6O4S |
| Molecular Weight: | 525.06 |
| Melting Point: | 214-216°C |
| Boiling Point: | 692.2°C at 760 mmHg |
| Flash point: | 372.5°C |
| Appearance: | White to Off-White Cyrstalline Solid |
CAS 224785-91-5 Product Picture
CAS 224785-91-5 Product Usage
CAS 224785-91-5 is a PDE5 inhibitor used for treating erectile dysfunction.Target: PDE5 Cas 224785-91-5 specifically inhibited the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). In contrast, the IC50 of Cas 224785-91-5 for PDE1 was 180 nM; for PDE6, 11 nM; for PDE2, PDE3 and PDE4, more than 1000 nM. Relative to PDE5, the ratios of the IC50 for PDE1 were 257 (60), for PDE6 16 (7.4). Cas 224785-91-5 significantly enhanced the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Cas 224785-91-5 also significantly potentiated both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle
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